@article{Zhang2024, 
author = {Hanming Zhang and Honglin Gao and Yicong Zhang and Yikun Han and Qing Lin and Tao Gong and Xun Sun and Zhirong Zhang and Ling Zhang and Shiqi Huang},
title = {Enzyme-activatable disk-shaped nanocarriers augment tumor permeability for breast cancer combination therapy},
year = {2024},
journal = {Nano Research},
volume = {17},
number = {7},
pages = {6400-6410},
keywords = {combination therapy, tumor penetration, charge reversal, nanodisk, γ-glutamyl transpeptidase},
url = {https://www.sciopen.com/article/10.1007/s12274-024-6608-3},
doi = {10.1007/s12274-024-6608-3},
abstract = {Unique physiopathological characteristics of tumor tissues impose obstacles to the sufficient penetration of traditional nanomedicines, resulting in undesirable drug delivery efficacy and therapeutic outcomes. Here, we constructed TRAIL-[ND-HCPT]GAC, a synergistic hydroxycamptothecin (HCPT) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein co-loaded disk-shaped nanocarrier with γ-glutamyl transpeptidase responsiveness. When the novel nanodisks extravasated into the tumor interstitium, the γ-glutamyl transpeptidase overexpressed on the tumor cell membranes cleaved the γ-glutamyl portions of the nanodisk surface to produce positively charged amino groups. As a result, the cationic nanodisks possessed stronger tumor infiltration ability through transcytosis than anionic nanodisks. HCPT and TRAIL exerted synergistic antitumor effects with better overall therapeutic efficacy. This TRAIL-[ND-HCPT]GAC system performed significantly better than free HCPT and remarkably prolonged the survival of breast tumor-bearing mice with no significant toxicity.}
}