@article{Qin2024, 
author = {Kevin Qin and Michael Yu and Jiaming Fan and Hongwei Wang and Piao Zhao and Guozhi Zhao and Wei Zeng and Connie Chen and Yonghui Wang and Annie Wang and Zander Schwartz and Jeffrey Hong and Lily Song and William Wagstaff and Rex C. Haydon and Hue H. Luu and Sherwin H. Ho and Jason Strelzow and Russell R. Reid and Tong-Chuan He and Lewis L. Shi},
title = {Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk},
year = {2024},
journal = {Genes & Diseases},
volume = {11},
number = {1},
pages = {103-134},
keywords = {β-catenin, Canonical Wnt, Noncanonical Wnt, Signal transduction, Signaling crosstalk},
url = {https://www.sciopen.com/article/10.1016/j.gendis.2023.01.030},
doi = {10.1016/j.gendis.2023.01.030},
abstract = {Wnt signaling plays a major role in regulating cell proliferation and differentiation. The Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either through β-catenin in the canonical pathway or through a series of other proteins in the noncanonical pathway. Many of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body, establishing the complex interplay between Wnt signaling and other signaling pathways. This crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ processes. Dysregulation of this system has been implicated in many diseases affecting a wide array of organ systems, including cancer and embryological defects, and can even cause embryonic lethality. The complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic treatments. However, both stimulatory and inhibitory treatments come with potential risks that need to be addressed. This review synthesized much of the current knowledge on the Wnt signaling pathway, beginning with the history of Wnt signaling. It thoroughly described the different variants of Wnt signaling, including canonical, noncanonical Wnt/PCP, and the noncanonical Wnt/Ca2+ pathway. Further description involved each of its components and their involvement in other cellular processes. Finally, this review explained the various other pathways and processes that crosstalk with Wnt signaling.}
}