TY  - JOUR
AU  - Oh, Won Young
AU  - Chiou, Yi-Shiou
AU  - Lee, Pei-Sheng
AU  - Pan, Min-Hsiung
AU  - Shahidi, Fereidoon
PY  - 2019
TI  - Lipophilized resveratrol affects the generation of reactive nitrogen species in murine macrophages and cell viability of human cancer cell lines
JO  - Journal of Food Bioactives
SN  - 2637-8752
SP  - 73
EP  - 77
VL  - 7
AB  - Resveratrol was esterified with selected fatty acids to improve its lipophilicity and potential application in food and biological systems. In this study, resveratrol and monoesters of resveratryl propionate (RC3:0) and resveratryl docosahexaenate (RDHA) were examined for their effects on anti-inflammatory and anti-proliferative activity in vitro. All test compounds showed a decreased nitrite production in murine RAW 264.7 cells in a concentration dependent manner. Resveratrol, RC3:0, and RDHA were evaluated for their effects on cell viability using liver cancer (HepG2), colon cancer (HT-29, A431), breast cancer (MCF7), and gastric cancer (AGS) cell lines. All test compounds showed decreased cell viability of HepG2, A431, MCF7, HT-29, and AGS in a concentration-dependent manner. The results suggest that resveratrol esters may serve as potential anti-inflammatory and anti-proliferative agents.
UR  - https://doi.org/10.31665/JFB.2019.7201
DO  - 10.31665/JFB.2019.7201