@article{Chen2024, 
author = {Kun Chen and Shengqiu Liu and Yujun Wei},
title = {Sub-nanosized vanadate hybrid clusters maintain glucose homeostasis and restore treatment response in inflammatory disease in obese mice},
year = {2024},
journal = {Nano Research},
volume = {17},
number = {3},
pages = {1818-1826},
keywords = {obesity, polyoxovanadates, glucose homeostasis, inflammatory disease, lipid modification, peroxisome proliferator-activated receptor γ (PPARγ)},
url = {https://www.sciopen.com/article/10.1007/s12274-023-6366-7},
doi = {10.1007/s12274-023-6366-7},
abstract = {Obesity is closely related with insulin resistance and chronic inflammation. Here, we report that unsaturated lipid-modified polyoxovanadates (ULPOVs) can restrict weight gain of diet-induced obese mice and improve their glycemic control and obesity-associated inflammation. Oral administration of the sub-nanosized ULPOVs at a low dosage for 7 weeks reduces the body weight and almost normalizes the blood glucose levels of obese mice fed on a high-fat diet. ULPOV treatment increases the activity of the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) and reduces intestinal caloric intake, which may be the main reason for blood sugar and body weight control. In addition to insulin-sensitizing, PPARγ activation induced by ULPOV treatment in obese mice with atopic dermatitis (AD) promotes the type 2 T helper (TH2) cell selective responses and therapeutic effects on immune dysregulation caused by obesity. These data suggest sub-nanosized polyoxovanadate clusters as a class of potential candidates to relieve symptoms accompanied by diet-induced obesity.}
}