@article{Liu2024, 
author = {Qing Liu and Teng Ma and Cuijiao Feng and Yalin Li and Hao Jin and Xuan Shi and Lai-Yu Kwok and Yan Shi and Tingtao Chen and Heping Zhang},
title = {Adjuvant postbiotic administration improves dental caries prognosis by restoring the oral microbiota},
year = {2024},
journal = {Food Science and Human Wellness},
volume = {13},
number = {5},
pages = {2690-2702},
keywords = {Dental caries, Postbiotics, Oral microbiota, Salivary microbiota, Pacific Biosciences (PacBio) single molecule real-time (SMRT) sequencing, Dental filling},
url = {https://www.sciopen.com/article/10.26599/FSHW.2022.9250217},
doi = {10.26599/FSHW.2022.9250217},
abstract = {Conventional filling therapy fails to fundamentally reduce oral cariogenic bacteria. Thus, oral microbiota follow-up intervention after filling would be necessary for improving dental caries prognosis. We recruited 9 caries-free individuals, and 89 dental caries subjects (5 dropouts). Eighty-nine patients were randomized into three groups: caries (n=8; no treatment), control (n=40; filling), and postbiotics (n=41; filling and 14-day Probio-Eco® intervention). Salivary samples were collected at 0 day (after filling) and 14 days. Our results showed that the diversity of dental caries oral microbiota was significantly increased compared with healthy subjects, and filling could restore a healthier oral microbiota partially and temporarily. Thepostbiotics intervention keeps a low alpha-diversity. Co-occurrence network analysis showed that a more stable oral microbiota structure after postbiotics intervention. Taxonomic and functional annotation of the microbiota revealed that postbiotics co-treatment significantly: increased the relative abundance of Pseudomonas and P. reactans, decreased the relative abundance of Prevotella shahii, and enriched the energy metabolism-related pathways. BugBase-predicted phenotypes inferred to an oral microbiota with decreased potential pathogenic bacteria and increased oxidative stress-tolerant bacteria after postbiotics intervention. Collectively, it suggested that postbiotics co-treatment could be a promising strategy that restores the oral microecological balance for dental caries.}
}