TY  - JOUR
AU  - Huang, Xingxing
AU  - Pan, Ting
AU  - Yan, Lili
AU  - Jin, Ting
AU  - Zhang, Ruonan
AU  - Chen, Bi
AU  - Feng, Jiao
AU  - Duan, Ting
AU  - Xiang, Yu
AU  - Zhang, Mingming
AU  - Chen, Xiaying
AU  - Yang, Zuyi
AU  - Zhang, Wenzheng
AU  - Ding, Xia
AU  - Xie, Tian
AU  - Sui, Xinbing
PY  - 2021
TI  - The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer
JO  - Genes & Diseases
SN  - 2352-4820
SP  - 781
EP  - 797
VL  - 8
IS  - 6
AB  - Accumulating evidence suggests that chronic inflammation may play a critical role in various malignancies, including bladder cancer. This hypothesis stems in part from inflammatory cells observed in the urethral microenvironment. Chronic inflammation may drive neoplastic transformation and the progression of bladder cancer by activating a series of inflammatory molecules and signals. Recently, it has been shown that the microbiome also plays an important role in the development and progression of bladder cancer, which can be mediated through the stimulation of chronic inflammation. In effect, the urinary microbiome can play a role in establishing the inflammatory urethral microenvironment that may facilitate the development and progression of bladder cancer. In other words, chronic inflammation caused by the urinary microbiome may promote the initiation and progression of bladder cancer. Here, we provide a detailed and comprehensive account of the link between chronic inflammation, the microbiome and bladder cancer. Finally, we highlight that targeting the urinary microbiome might enable the development of strategies for bladder cancer prevention and personalized treatment.
UR  - https://doi.org/10.1016/j.gendis.2020.10.002
DO  - 10.1016/j.gendis.2020.10.002