@article{Lee2024, 
author = {Hyo-Geun Lee and D.P. Nagahawatta and M.J.M.S. Kurera and Kyung-Mo Song and Yun-Sang Choi and You-Jin Jeon and Min-Cheol Kang},
title = {Effects of low molecular weight polysaccharide from Sargassum thunbergii against palmitic acid-induced intracellular lipid accumulation in 3T3-L1 adipocyte and HepG2 cells},
year = {2024},
journal = {Food Science and Human Wellness},
volume = {13},
number = {4},
pages = {2244-2252},
keywords = {Sargassum thunbergii, Low molecular weight polysaccharide, Lipid accumulation, Obesity, Liver steatosis},
url = {https://www.sciopen.com/article/10.26599/FSHW.2022.9250187},
doi = {10.26599/FSHW.2022.9250187},
abstract = {Low molecular weight polysaccharides can be isolated from Sargassum thunbergii (LMPST) and in vitro experiments were conducted to evaluate the inhibitory effects on lipids. Two natures of LMPST were attained from S. thunbergii and appraised their LMPST on palmitic acid (PA) induced lipid accretion in HepG2, and 3T3-L1 cells. LMPST treatment lessened lipid deposition and intracellular free fatty acid and triglyceride intensities in PA-treated above mentioned cells. The mechanistic study publicized that LMPST2 significantly suppressed adipogenesis and stimulated the PA-treated 3T3-L1 cells occupied in the lipolysis pathway. Furthermore, in PA-treated HepG2 cells, the free fatty acid oxidation was significantly increased by LMPST2. Given these constructive properties of LMPST2 from S. thunbergii, is a potential candidate for diminishing the intracellular lipids, and for a therapeutic agent in those conditions.}
}