TY  - JOUR
AU  - Zhang, Li
AU  - Yang, Changwei
AU  - Song, Yingxiang
AU  - Sheng, Tao
AU  - Li, Junyan
AU  - Yu, Jicheng
AU  - Wu, Xiaohong
AU  - Ye, Xiao
PY  - 2024
TI  - Advances of nanoparticles in transmucosal drug delivery
JO  - Nano Research
SN  - 1998-0124
SP  - 2874
EP  - 2885
VL  - 17
IS  - 4
AB  - Transmucosal drug administration represents a potential strategy for enhancing treatment efficacy and reducing side effects by avoiding the first-pass effect into the systemic circulation and delivering therapeutics directly to the target disease site. However, many challenges still remain in its clinical application, including low drug availability and limited retention time in the mucosa. The burgeoning advancement of nanotechnologies offers great potential to overcome the above limitations, leveraging their distinct advantages of high drug-loading capacity and strong permeability. In this review, the latest developments of nanoparticles (NPs) in transmucosal drug delivery as well as their clinical applications are discussed.
UR  - https://doi.org/10.1007/s12274-023-6188-7
DO  - 10.1007/s12274-023-6188-7