@article{Chai2024, 
author = {Yuwei Chai and Lin Chen and Shuya Xiang and Linxuan Wu and Xuebo Liu and Jun Luo and Xianchao Feng},
title = {Endoplasmic reticulum stress improved chicken tenderness, promoted apoptosis and autophagy during postmortem ageing},
year = {2024},
journal = {Food Science and Human Wellness},
volume = {13},
number = {4},
pages = {2141-2151},
keywords = {Endoplasmic reticulum stress, Tenderness, Apoptosis, Autophagy, Chicken},
url = {https://www.sciopen.com/article/10.26599/FSHW.2022.9250178},
doi = {10.26599/FSHW.2022.9250178},
abstract = {In this study, endoplasmic reticulum (ER) stress inducer tunicamycin (TM) and inhibitor 4-phenylbutyric acid (4-PBA) were used to treat postmortem chicken breast muscle to investigate changes in tenderness and effects on apoptosis and autophagy during 5 days ageing. TM-induced ER stress reduced shear force, enhanced myofibril fragmentation index (MFI), disrupted myofibril structure, increased desmin degradation, and activated μ-calpain and caspase-12. In addition, TM-induced ER stress increased the expression of Bax, Bim, and cytochrome c, and decreased the expression of Bcl-xL. Furthermore, TM-induced ER stress improved the conversion of LC3I to LC3II, raised the expression of Beclin-1, and decreased the expression of p62, PI3K, and mTOR. The opposite results were observed after 4-PBA treatment. These results suggested that ER stress could improve chicken tenderness, promote apoptosis and autophagy during chicken postmortem ageing.}
}