@article{Sharma2023, 
author = {Vandana Sharma and J. K. Sharma and Vishal Kansay and Varun Dutt Sharma and Rekha Sheoran and Manoj Singh and Chhavi Pahwa and Anupam Sharma and Suresh Kumar and A. K. Sharma and M. K. Bera},
title = {Chloramphenicol and Gentamycin-encapsulated Iron Oxide Nanoparticles as a Nanocarrier for Antibacterial Efficacy via Targeted Drug Delivery},
year = {2023},
journal = {Nano Biomedicine and Engineering},
volume = {15},
number = {2},
pages = {170-178},
keywords = {iron oxide nanoparticles (Fe2O3 NPs), antibacterial efficacy, biomimetic, drug delivery systems, chloramphenicol, gentamycin},
url = {https://www.sciopen.com/article/10.26599/NBE.2023.9290029},
doi = {10.26599/NBE.2023.9290029},
abstract = {Surface functionalization of iron oxide nanoparticles (Fe2O3 NPs) with antibiotics is a novel approach that opens the door to drug delivery applications. In the present work, we report iron oxide nanoparticles synthesized by chemical co-precipitation method. As-synthesized nanoparticles were characterized using field emission scanning electron microscopy (FESEM) , energy dispersive X-ray (EDX), X-ray diffraction (XRD), ultraviolet (UV)–visible (Vis) spectroscopy, Fourier transform infrared (FTIR), and vibrating sample magnetometer (VSM). The poly-shaped Fe2O3 NPs of size (34 ± 10) nm with hematite (α-Fe2O3) phase were synthesized. The antibacterial activity of chloramphenicol and gentamicin and their formulation with encapsulated iron oxide nanoparticles was investigated by the agar well diffusion technique. Drug-encapsulated Fe2O3 NPs showed antibacterial activity against Escherichia coli and Staphylococcus aureus strains, possibly in a dose-dependent manner. Significant effectiveness was confirmed by the increase in the single range of inhibition against the tested microorganisms. Furthermore, the effect of iron oxide nanoparticle concentrations ranging from 1 to 9 μg/μL on bacterial growth was examined.}
}