@article{Li2023, 
author = {Mohan Li and Yumiao He and Zongran Liu and Xu Ma and Fengrun Sun and Lijian Pei and Chao Ma and Hongju Liu and Tianjiao Ji and Yuguang Huang},
title = {Construction of meloxicam and bupivacaine co-delivery nanosystem based on the pathophysiological environment of surgical injuries for enhanced postoperative analgesia},
year = {2023},
journal = {Nano Research},
volume = {16},
number = {12},
pages = {13301-13308},
keywords = {core–shell nanostructure, multimodal analgesia, co-delivery system, postoperative pain management},
url = {https://www.sciopen.com/article/10.1007/s12274-023-6074-3},
doi = {10.1007/s12274-023-6074-3},
abstract = {Besides peripheral nerve injury, the acute inflammation is one of the pathological features of tissues after surgery, which exacerbates the postoperative pain, especially in the first 48 h after the surgery. Multimodal analgesia (MMA), such as the combination of non-steroidal anti-inflammatory drugs (NSAIDs) with local anesthetics, has shown enhanced potency compared with the usage of local anesthetics alone. However, rare formulations can provide long-term analgesia at a single dose. Herein, bupivacaine (BUP, a local anesthetic) loading poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPB) were coated with meloxicam (MLX, an NSAID) loading lipid bilayer (LPM), forming a core–shell nanosystem (NPB@LPM) to provide enhanced and long-term analgesia to treat postoperative pain. MLX was encapsulated in the lipid shell, which enabled high dose MLX to be released in the first 48 h after surgery to reduce the acute inflammation induced pain. BUP was encapsulated in the PLGA core to provide a long-term release for the nerve block. This nanosystem provided a 7-day (whole recovery cycle) effective analgesia in the Brennan’s plantar incision rat model. The tissue reactions of NPB@LPM are benign. This work will provide feasible strategies on designing drug delivery systems for postoperative pain management.}
}