@article{Xie2020, 
author = {Yingsi Xie and Ruslan G. Tuguntaev and Cong Mao and Haoting Chen and Ying Tao and Shixiang Wang and Bin Yang and Weisheng Guo},
title = {Stimuli-responsive polymeric nanomaterials for rheumatoid arthritis therapy},
year = {2020},
journal = {Biophysics Reports},
volume = {6},
number = {5},
pages = {193-210},
keywords = {Drug delivery systems, Nanotechnology, Rheumatoid arthritis, Stimuli-responsive polymers},
url = {https://www.sciopen.com/article/10.1007/s41048-020-00117-8},
doi = {10.1007/s41048-020-00117-8},
abstract = {Rheumatoid arthritis (RA) is a long-term inflammatory disease derived from an autoimmune disorder of the synovial membrane. Current therapeutic strategies for RA mainly aim to hamper the macrophages' proliferation and reduce the production of pro-inflammatory cytokines. Therefore, the accumulation of therapeutic agents targeted at the inflammatory site should be a crucial therapeutic strategy. Nowadays, the nanocarrier system incorporated with stimuli-responsive property is being intensively studied, showing the potentially tremendous value of specific therapy. Stimuli-responsive (i.e., pH, temperature, light, redox, and enzyme) polymeric nanomaterials, as an important component of nanoparticulate carriers, have been intensively developed for various diseases treatment. A survey of the literature suggests that the use of targeted nanocarriers to deliver therapeutic agents (nanotherapeutics) in the treatment of inflammatory arthritis remains largely unexplored. The lack of suitable stimuli-sensitive polymeric nanomaterials is one of the limitations. Herein, we provide an overview of drug delivery systems prepared from commonly used stimuli-sensitive polymeric nanomaterials and some inorganic agents that have potential in the treatment of RA. The current situation and challenges are also discussed to stimulate a novel thinking about the development of nanomedicine.}
}