@article{Feng2023, 
author = {Xueyan Feng and Bei Liu and Zehao Zhou and Wei Li and Jian Zhao and Lele Li and Yuliang Zhao},
title = {Engineering hierarchical metal-organic@metal-DNA heterostructures for combinational tumor treatment},
year = {2023},
journal = {Nano Research},
volume = {16},
number = {11},
pages = {12633-12640},
keywords = {metal-organic frameworks, DNA, coordination, hierarchical nanostructures, combinational tumor treatment},
url = {https://www.sciopen.com/article/10.1007/s12274-023-5909-2},
doi = {10.1007/s12274-023-5909-2},
abstract = {Development of simple methods for controlled integration of DNA molecules with metal-organic frameworks (MOFs) is important for various biomedical applications, yet remains a challenge. Herein, a simple and general approach to load DNA on the surface of MOFs is developed via one-pot self-assembly of DNA and FeII ions on nanoscale MOFs, resulting in hierarchical core-shell nanostructures of metal-organic@metal-DNA coordination polymers. The strategy enables assembly of DNA molecules on MOFs with ultra-high contents and precise controllability. By incorporation of a chemotherapeutic drug into the Fe-DNA shell, the systems allow to integrate chemotherapy and gene therapy with photodynamic therapy for combinational tumor treatment. Moreover, the hybrid nanostructures enable light-triggered production of cytotoxic singlet oxygen, which further boosts the endosomal escape of the system for an enhanced gene silencing efficacy and thus improved therapeutic outcome. This work highlights a robust approach for the construction of coordination-based drug delivery systems to combat tumor.}
}