@article{Bai2023, 
author = {Yang Bai and Xihua Li and Sijie Song and Jing Yang and Xia Liu and Zhaowei Chen},
title = {Pillar[6]arene-based supramolecular self-assemblies for two-pronged GSH-consumption-augmented chemo/photothermal therapy},
year = {2023},
journal = {Nano Research},
volume = {16},
number = {7},
pages = {9921-9929},
keywords = {supramolecular self-assemblies, pillar[6]arene, glutathione  consumption, chemo/photothermal therapy},
url = {https://www.sciopen.com/article/10.1007/s12274-023-5858-9},
doi = {10.1007/s12274-023-5858-9},
abstract = {The abundant intracellular glutathione (GSH) in cancer cells severely undermines the therapeutic efficacy of different treatments due to their role in protecting cancer cells from the associated oxidative stress. Developing a highly integrated system to consume GSH would help to improve the therapeutic outcomes. In this study, supramolecular prodrug self-assemblies (SPSAs) with IR825 loaded inside were developed to consume GSH via two-pronged pathways while augmenting the therapeutic potency of chemo/photothermal treatment. SPSAs were prepared using water-soluble pillar[6]arene (WP[6]) as host units and H2O2-responsive nitrogen mustard prodrug, chlorambucil-(phenylboronic acid pinacol ester) conjugates (Cb-BE), as the guests. When SPSAs were internalized by cancer cells, the generation of quinone methide (QM) from Cb-BE and singlet oxygen (1O2) from irradiation-activated IR825 could consume GSH in a concerted way. As such, the therapeutic efficacies of the released chlorambucil and the accompanied hyperthermia were augmented toward synergistically inhibiting tumor growth.}
}