@article{Zhang2017, 
author = {Yancong Zhang and Li Zhou and Weiwei Ma and Xiaosa Shi and Hongmei Zhang and Xinyuan Shi},
title = {Bidirectional solid fermentation using Trametes robiniophila Murr. for enhancing efficacy and reducing toxicity of rhubarb (Rheum palmatum L.)},
year = {2017},
journal = {Journal of Traditional Chinese Medical Sciences},
volume = {4},
number = {3},
pages = {306-313},
keywords = {Rhubarb, Trametes robiniophila Murr., Bidirectional solid fermentation, Anthraquinones, Cancer inhibition},
url = {https://www.sciopen.com/article/10.1016/j.jtcms.2017.07.010},
doi = {10.1016/j.jtcms.2017.07.010},
abstract = {ObjectiveTo investigate the potential of bidirectional solid fermentation of rhubarb (Rheum palmatum L.) for reducing its toxicity and enhancing its medicinal efficacy.MethodsThe fungus Trametes robiniophila Murr. was inoculated into rhubarb. The chemical ingredients as well as antioxidant, antibacterial, and anticancer activities of fermented and unfermented rhubarb extracts were then determined.ResultsAfter fermentation, levels of anthraquinone glycosides (purgative ingredients) decreased significantly, while the level of anthraquinone aglycone increased. The level of gallic acid was also reduced after fermentation. Ethanol extract of rhubarb (0.8 mg/mL) exhibited DPPH-scavenging activity of 7.6% ± 0.8%, while the blank control (0.8 mg/mL rhubarb) showed 31.3% ± 2.0% activity. Antibacterial activities in fermented samples were found to be enhanced compared with unfermented samples and anticancer activity was evident at concentrations of 2000 and 5000 μg/mL.ConclusionBidirectional solid fermentation appears to be an effective processing method that can be used to improve the efficacy and reduce the toxicity of rhubarb.}
}