TY  - JOUR
AU  - Xu, Min
AU  - Wang, Yu-Meng
AU  - Li, Wan-Qing
AU  - Huang, Cheng-Long
AU  - Li, Jun
AU  - Xie, Wen-Hua
AU  - Zeng, Hong-Xiang
AU  - Tao, Lin-Fen
AU  - Li, Xi
PY  - 2022
TI  - Ccrl2 deficiency deteriorates obesity and insulin resistance through increasing adipose tissue macrophages infiltration
JO  - Genes & Diseases
SN  - 2352-4820
SP  - 429
EP  - 442
VL  - 9
IS  - 2
AB  - Obesity-induced inflammation, characterized by augmented infiltration and altered balance of macrophages, is a critical component of systemic insulin resistance. Chemokine-chemokine receptor system plays a vital role in the macrophages accumulation. CC-Chemokine Receptor-like 2 (Ccrl2) is one of the receptors of Chemerin, which is a member of atypical chemokine receptors (ACKR) family, reported taking part in host immune responses and inflammation-related conditions. In our study, we found ccrl2 expression significantly elevated in visceral adipose tissue (VAT) of high fat diet (HFD) induced obese mice and ob/ob mice. Systemic deletion of Ccrl2 gene aggravated HFD induced obesity and insulin resistance and ccrl2 mice showed aggravated VAT inflammation and increased M1/M2 macrophages ratio, which is due to the increase of macrophages chemotaxis in Ccrl2 deficiency mice. Cumulatively, these results indicate that Ccrl2 has a critical function in obesity and obesity-induced insulin resistance via mediating macrophages chemotaxis.
UR  - https://doi.org/10.1016/j.gendis.2020.08.009
DO  - 10.1016/j.gendis.2020.08.009