@article{Pu2022, 
author = {Feifei Pu and Fengxia Chen and Zhicai Zhang and Deyao Shi and Binlong Zhong and Xiao Lv and Andrew Blake Tucker and Jiaming Fan and Alexander J. Li and Kevin Qin and Daniel Hu and Connie Chen and Hao Wang and Fang He and Na Ni and Linjuan Huang and Qing Liu and William Wagstaff and Hue H. Luu and Rex C. Haydon and Le Shen and Tong-Chuan He and Jianxiang Liu and Zengwu Shao},
title = {Ferroptosis as a novel form of regulated cell death: Implications in the pathogenesis, oncometabolism and treatment of human cancer},
year = {2022},
journal = {Genes & Diseases},
volume = {9},
number = {2},
pages = {347-357},
keywords = {Cancer, Cancer therapy, Clinical application, Ferroptosis, Lipid peroxidation, Pathogenesis},
url = {https://www.sciopen.com/article/10.1016/j.gendis.2020.11.019},
doi = {10.1016/j.gendis.2020.11.019},
abstract = {The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy. Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells. Anti-tumor drugs were developed to induce apoptosis, but some patient's show apoptosis escape and chemotherapy resistance. Therefore, other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment. Ferroptosis is a newly discovered iron-dependent, non-apoptotic type of cell death that is highly negatively correlated with cancer development. Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis. This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment.}
}