@article{Li2023, 
author = {Jing Li and Xinyue Yu and Xinxing Xu and Peipei Tang and Shuang Bi and Xiaopu Ren and Yong Shi and Jihong Wu and Fei Lao},
title = {Beneficial effects of fermented jujube pulp in relieving loperamide hydrochloride-induced constipation in male ICR mice},
year = {2023},
journal = {Food Science and Human Wellness},
volume = {12},
number = {6},
pages = {2286-2296},
keywords = {Jujube, Lactic acid bacteria fermentation, Short-chain fatty acid, Probiotics, Gut microbiota},
url = {https://www.sciopen.com/article/10.1016/j.fshw.2023.03.048},
doi = {10.1016/j.fshw.2023.03.048},
abstract = {Unfermented jujube pulp (UFJP), fermented jujube pulp (FJP) in high and low doses were fed to constipated ICR mice. Defecation function, serum gastrointestinal regulatory peptide, fecal short-chain fatty acids (SCFAs) and gut microbial composition were assessed. Results showed that high-dose FJP could protect intestinal mucosa tissue, shorten the first black feces defecating time by 17% and increase the number and wet weights of black feces by 72% and 71%, respectively, within 6 h. High-dose FJP significantly down-regulated the somatostatin level and up-regulated gastrin level in constipated mice, compared with low-dose FJP and UFJP. High-dose FJP intervention regulated the microbiota profile, which afterwards restored microbiota, like Bacteroidetes, Bifidobacterium and Lactobacillus, to a less unhealthy state. This study provides convincing in vivo evidence that high-dose FJP supplementation through daily diet could be a promising approach to effectively alleviate constipation and modulate gut health.}
}