TY  - JOUR
AU  - Sun, Ranran
AU  - Li, Lingru
AU  - Yao, Haiqiang
AU  - Chen, Yu
AU  - Li, Pin
AU  - Sun, Jianxiang
AU  - Qin, Yuehua
AU  - Wang, Xin
AU  - Wang, Qi
PY  - 2018
TI  - Association between body-constitution type and vascular endothelial dysfunction: A cross-sectional study in an adult obese/overweight population
JO  - Journal of Traditional Chinese Medical Sciences
SN  - 2095-7548
SP  - 94
EP  - 99
VL  - 5
IS  - 2
AB  - ObjectiveTo measure vascular endothelial function (VED) in obese/overweight people grouped according to the constitutional theory of traditional Chinese medicine (TCM). We wished to predict the risk of VED and cardiovascular diseases in obese/overweight populations.MethodsThis was a cross-sectional study. Eighty-six obese/overweight volunteers from Beijing Chao-Yang Hospital were enrolled and divided into four groups based on body-constitution type: phlegm dampness (PD); phlegm dampness with blood stasis (PDBS); qi-deficiency (QD); balance (BA). Height, weight, waist circumference and hip circumference were measured, and percent body fat and reactive hyperemia index (RHI) calculated. Levels of vascular endothelial growth factor (VEGF), von Willebrand factor (vWF) and plasma endothelial-1 (ET-1) were detected by immunohistochemistry.ResultsThe RHI and vWF levels in the PDBS group were significantly lower than those in the BA group and QD group (P < .05), but there was no significant difference compared with the PD group (P > .05). These two indicators displayed no significant differences among BA, QD, and PD groups (P > .05). There was no significant difference among the four groups in level of ET-1 or VEGF (P > .05).ConclusionOf the four indicators selected, the RHI and vWF displayed significant differences between the PDBS group and BA group, and between the PDBS group and QD group. Hence, in an obese/overweight population with different constitutional types, compared with BA and QD groups, a relatively higher risk of suffering from VED was detected in the PDBS group. Meanwhile, this study provides the experimental basis for confirming the feasibility of constitutional classification in obese/overweight population.
UR  - https://doi.org/10.1016/j.jtcms.2018.05.003
DO  - 10.1016/j.jtcms.2018.05.003