@article{Huang2022, 
author = {Xia Huang and Qiuman Chen and Wenping Luo and Mikhail Pakvasa and Yuxin Zhang and Liwen Zheng and Shuang Li and Zhuohui Yang and Huan Zeng and Fang Liang and Fugui Zhang and Daniel A. Hu and Kevin H. Qin and Eric J. Wang and David S. Qin and Russell R. Reid and Tong-Chuan He and Aravind Athiviraham and Mostafa El Dafrawy and Hongmei Zhang},
title = {SATB2: A versatile transcriptional regulator of craniofacial and skeleton development, neurogenesis and tumorigenesis, and its applications in regenerative medicine},
year = {2022},
journal = {Genes & Diseases},
volume = {9},
number = {1},
pages = {95-107},
keywords = {Bone regeneration, Development, Neurogenesis, SATB2, Tumorigenesis},
url = {https://www.sciopen.com/article/10.1016/j.gendis.2020.10.003},
doi = {10.1016/j.gendis.2020.10.003},
abstract = {SATB2 (special AT-rich sequence-binding protein 2) is a member of the special AT-rich binding protein family. As a transcription regulator, SATB2 mainly integrates higher-order chromatin organization. SATB2 expression appears to be tissue- and stage-specific, and is governed by several cellular signaling molecules and mediators. Expressed in branchial arches and osteoblast-lineage cells, SATB2 plays a significant role in craniofacial pattern and skeleton development. In addition to regulating osteogenic differentiation, SATB2 also displays versatile functions in neural development and cancer progression. As an osteoinductive factor, SATB2 holds great promise in improving bone regeneration toward bone defect repair. In this review, we have summarized our current understanding of the physiological and pathological functions of SATB2 in craniofacial and skeleton development, neurogenesis, tumorigenesis and regenerative medicine.}
}