TY  - JOUR
AU  - Huang, Xia
AU  - Chen, Qiuman
AU  - Luo, Wenping
AU  - Pakvasa, Mikhail
AU  - Zhang, Yuxin
AU  - Zheng, Liwen
AU  - Li, Shuang
AU  - Yang, Zhuohui
AU  - Zeng, Huan
AU  - Liang, Fang
AU  - Zhang, Fugui
AU  - Hu, Daniel A.
AU  - Qin, Kevin H.
AU  - Wang, Eric J.
AU  - Qin, David S.
AU  - Reid, Russell R.
AU  - He, Tong-Chuan
AU  - Athiviraham, Aravind
AU  - El Dafrawy, Mostafa
AU  - Zhang, Hongmei
PY  - 2022
TI  - SATB2: A versatile transcriptional regulator of craniofacial and skeleton development, neurogenesis and tumorigenesis, and its applications in regenerative medicine
JO  - Genes & Diseases
SN  - 2352-4820
SP  - 95
EP  - 107
VL  - 9
IS  - 1
AB  - SATB2 (special AT-rich sequence-binding protein 2) is a member of the special AT-rich binding protein family. As a transcription regulator, SATB2 mainly integrates higher-order chromatin organization. SATB2 expression appears to be tissue- and stage-specific, and is governed by several cellular signaling molecules and mediators. Expressed in branchial arches and osteoblast-lineage cells, SATB2 plays a significant role in craniofacial pattern and skeleton development. In addition to regulating osteogenic differentiation, SATB2 also displays versatile functions in neural development and cancer progression. As an osteoinductive factor, SATB2 holds great promise in improving bone regeneration toward bone defect repair. In this review, we have summarized our current understanding of the physiological and pathological functions of SATB2 in craniofacial and skeleton development, neurogenesis, tumorigenesis and regenerative medicine.
UR  - https://doi.org/10.1016/j.gendis.2020.10.003
DO  - 10.1016/j.gendis.2020.10.003