@article{Long2018, 
author = {Xingyao Long and Yanni Pan and Xin Zhao},
title = {Prophylactic effect of Kudingcha polyphenols on oxazolone induced colitis through its antioxidant capacities},
year = {2018},
journal = {Food Science and Human Wellness},
volume = {7},
number = {3},
pages = {209-214},
keywords = {Kudingcha polyphenols, Oxazolone, Antioxidant, Colitis, mRNA expression},
url = {https://www.sciopen.com/article/10.1016/j.fshw.2018.06.002},
doi = {10.1016/j.fshw.2018.06.002},
abstract = {This research the preventive effect of Kudingcha polyphenols (Kp) on colitis based on animal experiments. Experimental mice divided into four groups, including normal group, model group, low-concentration Kp (LKP) group and high-concentration Kp (HKP) group, and they all smeared and given 0.15mL 1% oxazolone solution by lavage to induce BALB/c mice colitis. DAI, colon weight/length ratio, serum levels of cytokines, related antioxidant activities of colon tissues such, and the mRNA expressions. The experimental results show that KP can significantly (p < 0.05) reduce DAI in mice with colitis and inhibit shortening of colon caused by colitis, increase colon weight/length ratio. It can also significantly reduce (p < 0.05) the activities of MPO, NO, MDA in mice colon tissues with colitis, increase the activity of GSH, and significantly increase (p < 0.05) the level of IL-2 and decrease the level of IL-10 in mice serum with colitis. The results of qPCR assay show that Kp can significantly increase (p < 0.05) the expression of Cu/Zn-SOD, Mn-SOD, GSH-Px, CAT, c-Kit, SCF and decrease the expression of IL-8, CXCR2 in mice colon tissues with colitis. Kp has a good preventive effect on colitis, and high concentration of PT has better preventive effect.}
}