@article{Yu2023, 
author = {Yue Yu and Yinuo Zhang and Yu Wang and Wenxing Chen and Zhanjun Guo and Ningning Song and Minmin Liang},
title = {Multiscale structural design of MnO2@GO superoxide dismutase nanozyme for protection against antioxidant damage},
year = {2023},
journal = {Nano Research},
volume = {16},
number = {8},
pages = {10763-10769},
keywords = {specificity, activity, antioxidation, superoxide dismutase (SOD)-like activity, MnO2@graphene oxide (MnO2@GO) nanozyme},
url = {https://www.sciopen.com/article/10.1007/s12274-023-5760-5},
doi = {10.1007/s12274-023-5760-5},
abstract = {Rational design of metallic active sites and its microenvironment is critical for constructing superoxide dismutase (SOD) nanozymes. Here, we reported a novel SOD nanozyme design, with employing graphene oxide (GO) as the framework, and δ-MnO2 as the active sites, to mimic the natural Mn-SOD. This MnO2@GO nanozyme exhibited multiscale laminated structures with honeycomb-like morphology, providing highly specific surface area for ·O2− adsorption and confined spaces for subsequent catalytic reactions. Thus, the nanozyme achieved superlative SOD-like catalytic performance with inhibition rate of 95.5%, which is 222.6% and 1605.4% amplification over GO and MnO2 nanoparticles, respectively. Additionally, such unique hierarchical structural design endows MnO2@GO with catalytic specificity, which was not present in the individual component (GO or MnO2). This multiscale structural design provides new strategies for developing highly active and specific SOD nanozymes.}
}