@article{Indrianingsih2017, 
author = {Anastasia Wheni Indrianingsih and Sanro Tachibana},
title = {α-Glucosidase inhibitor produced by an endophytic fungus, Xylariaceae sp. QGS 01 from Quercus gilva Blume},
year = {2017},
journal = {Food Science and Human Wellness},
volume = {6},
number = {2},
pages = {88-95},
keywords = {Endophytic fungi, Quercus qilva Blume, α-Glucosidase inhibitory activity, Xylariaceae sp., Isocoumarine derivative},
url = {https://www.sciopen.com/article/10.1016/j.fshw.2017.05.001},
doi = {10.1016/j.fshw.2017.05.001},
abstract = {Xylariaceae sp. QGS 01, an endophytic fungus isolated from the stem of Quercus gilva Blume showed high α-glucosidase inhibitory activity. α-Glucosidase inhibitor have the role as one of carbohydrate-hydrolyzing enzymes to postpone absorption of glucose in the digestive organs. The α-glucosidase inhibitor constituents were isolated from the ethyl acetate extract of the mycellium of endophytic fungi Xylariaceae sp. QGS 01 using a bioassay-guided fractionation technique. Further separation and purification of the active fraction led to the isolation of constituents with strong inhibitory activities against α-glucosidase: 8-hydroxy-6,7-dimethoxy-3-methylisocoumarine (1) with inhibitory concentration (IC50) values against α-glucosidase from Saccharomyces cerevisiae of 41.75 μg/mL, while quercetin as the standard had an IC50 value of 4.80 μg/mL. The results of the present study showed that the endophytic fungus Xylariaceae sp. QGS 01 is potentially a rich source of antidiabetic medicine.}
}