TY  - JOUR
AU  - Indrianingsih, Anastasia Wheni
AU  - Tachibana, Sanro
PY  - 2017
TI  - α-Glucosidase inhibitor produced by an endophytic fungus, Xylariaceae sp. QGS 01 from Quercus gilva Blume
JO  - Food Science and Human Wellness
SN  - 2097-0765
SP  - 88
EP  - 95
VL  - 6
IS  - 2
AB  - Xylariaceae sp. QGS 01, an endophytic fungus isolated from the stem of Quercus gilva Blume showed high α-glucosidase inhibitory activity. α-Glucosidase inhibitor have the role as one of carbohydrate-hydrolyzing enzymes to postpone absorption of glucose in the digestive organs. The α-glucosidase inhibitor constituents were isolated from the ethyl acetate extract of the mycellium of endophytic fungi Xylariaceae sp. QGS 01 using a bioassay-guided fractionation technique. Further separation and purification of the active fraction led to the isolation of constituents with strong inhibitory activities against α-glucosidase: 8-hydroxy-6,7-dimethoxy-3-methylisocoumarine (1) with inhibitory concentration (IC50) values against α-glucosidase from Saccharomyces cerevisiae of 41.75 μg/mL, while quercetin as the standard had an IC50 value of 4.80 μg/mL. The results of the present study showed that the endophytic fungus Xylariaceae sp. QGS 01 is potentially a rich source of antidiabetic medicine.
UR  - https://doi.org/10.1016/j.fshw.2017.05.001
DO  - 10.1016/j.fshw.2017.05.001