TY  - JOUR
AU  - Touiss, Ilham
AU  - Khatib, Saloua
AU  - Bekkouch, Oussama
AU  - Amrani, Souliman
AU  - Harnafi, Hicham
PY  - 2017
TI  - Phenolic extract from Ocimum basilicum restores lipid metabolism in Triton WR-1339-induced hyperlipidemic mice and prevents lipoprotein-rich plasma oxidation
JO  - Food Science and Human Wellness
SN  - 2097-0765
SP  - 28
EP  - 33
VL  - 6
IS  - 1
AB  - In this study we investigated the hypolipidemic and anti-lipoprotein-oxidation activities of phenolic extract from sweet basil a popular culinary herb. The hypolipidemic activity was studied in mice model injected intraperitoneally with Triton WR-1339 at a dose of 200 mg/kg body weight. The animals were grouped as follows: normolipidemic control group (n = 8), hyperlipidemic control group (n = 8) and phenolic extract-treated group (n = 8) at a dose of 200 mg/kg body weight. After 7 h and 24 h treatment, the oral administration of the phenolic extract exerts a significant reduction of plasma total cholesterol, triglycerides and LDL-cholesterol concentrations (P<0.001). On the other hand, we demonstrated that the phenolic extract prevents plasma lipid oxidation by 16% (P<0.001), 20% (P<0.001), 32% (P<0.001) and 44% (P<0.001) at a doses of 10, 25, 50 and 100 μg/mL, respectively. The results were compared with ascorbic acid used as standard synthetic antioxidant. HPLC analysis shows that the extract contains 4 major phenolics and is especially rich in rosmarinic acid. This finding indicates that the phenolic extract might be beneficial in lowering hyperlipidemia and preventing atherosclerosis.
UR  - https://doi.org/10.1016/j.fshw.2017.02.002
DO  - 10.1016/j.fshw.2017.02.002