@article{Akinmoladun2017, 
author = {Afolabi C. Akinmoladun and Kehinde O. Oguntunde and Lawrence O. Owolabi and Omotayo B. Ilesanmi and Joan O. Ogundele and M.Tolulope Olaleye and Afolabi A. Akindahunsi},
title = {Reversal of acetaminophen-generated oxidative stress and concomitant hepatotoxicity by a phytopharmaceutical product},
year = {2017},
journal = {Food Science and Human Wellness},
volume = {6},
number = {1},
pages = {20-27},
keywords = {Acetaminophen, Antioxidant activity, Hepatoprotection, Nutraceutical, Herbal supplement},
url = {https://www.sciopen.com/article/10.1016/j.fshw.2016.11.001},
doi = {10.1016/j.fshw.2016.11.001},
abstract = {The increasing popularity of herbal medicine and the well-established health benefits of phytochemicals have spurred the multiplicity of nutraceutical and phytopharmaceutical products. In this study, TrévoTM, a nutraceutical and phytopharmaceutical product, was evaluated for beneficial effects in acetaminophen-induced hepatic toxicity in Wistar rats. Animals received TrévoTM (1.5 mL/kg, 3.0 mL/kg or 4.5 mL/kg) orally for 14 days. Hepatotoxicity was induced by the oral administration of acetaminophen (2 g/kg), 24 h prior to sacrifice. Biochemical liver function tests, oxidative stress indicators and histoarchitectural changes were evaluated. Acetaminophen administration occasioned significant increase (P<0.05) in serum bilirubin level and activities of the aminotransferases, alkaline phosphatase, γ-glutamyltransferase and lactate dehydrogenase accompanied by a significant decrease (P<0.05) in albumin level as well as histopathological alterations in liver sections. Promotion of hepatic oxidative stress by acetaminophen was revealed by significant (P<0.05) increase in lipid peroxidation, depletion of reduced glutathione, and decrease in superoxide dismutase and catalase activities. Administration of TrévoTM remarkably ameliorated acetaminophen-induced histopathological alterations and changes in serum and tissue biochemical markers. The protective effect of TrévoTM (4.5 mL/kg) was at par with that of Silymarin (25 mg/kg). The present study indicates that TrévoTM has notable salubrious effects.}
}