TY  - JOUR
AU  - Akinmoladun, Afolabi C.
AU  - Oguntunde, Kehinde O.
AU  - Owolabi, Lawrence O.
AU  - Ilesanmi, Omotayo B.
AU  - Ogundele, Joan O.
AU  - Olaleye, M.Tolulope
AU  - Akindahunsi, Afolabi A.
PY  - 2017
TI  - Reversal of acetaminophen-generated oxidative stress and concomitant hepatotoxicity by a phytopharmaceutical product
JO  - Food Science and Human Wellness
SN  - 2097-0765
SP  - 20
EP  - 27
VL  - 6
IS  - 1
AB  - The increasing popularity of herbal medicine and the well-established health benefits of phytochemicals have spurred the multiplicity of nutraceutical and phytopharmaceutical products. In this study, TrévoTM, a nutraceutical and phytopharmaceutical product, was evaluated for beneficial effects in acetaminophen-induced hepatic toxicity in Wistar rats. Animals received TrévoTM (1.5 mL/kg, 3.0 mL/kg or 4.5 mL/kg) orally for 14 days. Hepatotoxicity was induced by the oral administration of acetaminophen (2 g/kg), 24 h prior to sacrifice. Biochemical liver function tests, oxidative stress indicators and histoarchitectural changes were evaluated. Acetaminophen administration occasioned significant increase (P<0.05) in serum bilirubin level and activities of the aminotransferases, alkaline phosphatase, γ-glutamyltransferase and lactate dehydrogenase accompanied by a significant decrease (P<0.05) in albumin level as well as histopathological alterations in liver sections. Promotion of hepatic oxidative stress by acetaminophen was revealed by significant (P<0.05) increase in lipid peroxidation, depletion of reduced glutathione, and decrease in superoxide dismutase and catalase activities. Administration of TrévoTM remarkably ameliorated acetaminophen-induced histopathological alterations and changes in serum and tissue biochemical markers. The protective effect of TrévoTM (4.5 mL/kg) was at par with that of Silymarin (25 mg/kg). The present study indicates that TrévoTM has notable salubrious effects.
UR  - https://doi.org/10.1016/j.fshw.2016.11.001
DO  - 10.1016/j.fshw.2016.11.001