@article{Li2023, 
author = {Na Li and Wan Liu and Xiaoyan Zheng and Qing Wang and Lixin Shen and Junfeng Hui and Daidi Fan},
title = {Antimicrobial hydrogel with multiple pH-responsiveness for infected burn wound healing},
year = {2023},
journal = {Nano Research},
volume = {16},
number = {8},
pages = {11139-11148},
keywords = {P-ZIF nanoparticles, hydrogel dressing, antibacterial, pH-responsive, burn wound healing},
url = {https://www.sciopen.com/article/10.1007/s12274-023-5751-6},
doi = {10.1007/s12274-023-5751-6},
abstract = {Burns are a common medical problem globally, and wound infection is one of the major causes of inducing related complications. Although antibiotics effectively prevent wound infections, the misuse of antibiotics has created a new problem of superbugs. Herein, we propose a new strategy to obtain pH-responsive antimicrobial P-ZIF (ZIF: zeolitic imidazolate framework) by loading polyhexamethylenebiguanide (PHMB) into the framework of ZIF-8 nanoparticles. This will enable PHMB to be released in the weak acid environment of an infected wound. To address burn infections, P-ZIF nanoparticles were loaded into a hydrogel system made of sodium alginate (SA) and 3-aminophenylboronic acid modified human-like collagen (H-A) through borate ester bonds. The resulting H-A/SA/P-ZIF (HASPZ) hydrogel dressing not only possesses antibacterial and wound healing properties but also has dual pH responsiveness to prevent the overuse of medication while effectively treat deep second-degree burns. Therefore, P-ZIF nanoparticles and the corresponding HASPZ hydrogel dressing are considered of significant importance in antimicrobial, drug delivery, and wound repair.}
}