@article{Xi2023, 
author = {Hongyan Xi and Hongfei Gu and Yurui Han and Tingting You and Pengfei Wu and Qingqing Liu and Lirong Zheng and Shuhu Liu and Qiang Fu and Wenxing Chen and Yukun Gao and Yuting Wang and Penggang Yin},
title = {Peroxidase-like single Fe atoms anchored on Ti3C2Tx MXene as surface enhanced Raman scattering substrate for the simultaneous discrimination of multiple antioxidants},
year = {2023},
journal = {Nano Research},
volume = {16},
number = {7},
pages = {10053-10060},
keywords = {single atom catalyst, surface enhanced Raman scattering (SERS), Ti3C2Tx MXene, antioxidants, atomic interface site},
url = {https://www.sciopen.com/article/10.1007/s12274-023-5739-2},
doi = {10.1007/s12274-023-5739-2},
abstract = {Single-atom nanozymes (SAzymes) are emerging as promising alternatives to mimic natural enzyme, which is due to high atomic utilization efficiency, well-defined geometric, and unique electronic structure. Herein, Fe single atoms supported on Ti3C2Tx (Fe-SA/Ti3C2Tx) with intrinsic peroxidase activity is developed, further constructing a sensitive Raman sensor array for sensing of five antioxidants. Fe-SA/Ti3C2Tx shows excellent peroxidase-like performance in catalyzing the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) with colorimetric reactions. X-ray adsorption fine structure (XAFS) reveals that the electron transport between the Ti3C2Tx and Fe atoms occurs along Fe-O-Ti ligands, meanwhile the density functional theory (DFT) calculations confirm the spontaneous dissociation of H2O2 and the formation of OH radicals. Furthermore, the peroxidase-like Fe-SA/Ti3C2Tx was used as surface enhanced Raman scattering (SERS) substrate of oxidized TMB (TMB+) and achieved satisfied signal amplification performance. Using the blocking effects of free radical reactions, one-off identification of 5 antioxidants, including ascorbic acid (AA), uric acid (UA), glutathione (GSH), melatonin (Mel), and tea polyphenols (TPP), could be realized with this high identifiable catalytic property. This principle could realize 100% distinguish accuracy combined with linear discriminant analysis (LDA) and heat map data analysis. A wide detection concentration ranges from 10−8 to 10−3 M for five antioxidants was also achieved.}
}