@article{Tang2023, 
author = {Lijuan Tang and Zhenghan Di and Jingfang Zhang and Feiying Yin and Lele Li and Li Zheng},
title = {Coordination-driven self-assembly of metallo-nanodrugs for local inflammation alleviation},
year = {2023},
journal = {Nano Research},
volume = {16},
number = {12},
pages = {13259-13266},
keywords = {drug delivery, nanomedicine, coordination-driven assembly, anti-inflammation therapy},
url = {https://www.sciopen.com/article/10.1007/s12274-023-5721-z},
doi = {10.1007/s12274-023-5721-z},
abstract = {Developing dedicated nanomedicines to improve delivery efficacy of anti-inflammatory drugs is still a formidable challenge. In this study, we present an extremely simple yet efficient approach to obtain hybrid nanodrugs through metal-drug coordination-driven self-assembly for carrier-free drug delivery. The resulting metallo-nanodrugs exhibit well-defined morphology and high drug encapsulation capability, allowing for the combination of magnetic resonance imaging and anti-inflammatory therapy. In the case of osteoarthritis (OA), the metallo-nanodrugs remarkably alleviate synovial inflammation, preventing cartilage destruction and extracellular matrix loss. In addition, it led to significantly improved therapeutic efficacy compared with intra-articular administration of the same dose of free drugs in OA mouse model. This work provides a very simple approach for the development of anti-inflammatory nanoformulations by exploiting coordination-driven self-assembly.}
}