@article{Yang2024, 
author = {Lan Yang and Lai-Yu Kwok and Zhihong Sun and Heping Zhang},
title = {Lacticaseibacillus rhamnosus Probio-M9 may be vertically transmitted from mother to infant during lactation based on faeces metagenomics},
year = {2024},
journal = {Food Science and Human Wellness},
volume = {13},
number = {2},
pages = {721-728},
keywords = {Infant, Gut microbiome, Metagenomic analysis, Lacticaseibacillus rhamnosus, Mother},
url = {https://www.sciopen.com/article/10.26599/FSHW.2022.9250061},
doi = {10.26599/FSHW.2022.9250061},
abstract = {Probiotics exert beneficial effects on the host. This study aimed to investigate whether maternally ingested Lacticaseibacillus rhamnosus Probio-M9 during pregnancy could access and colonize the infant gut. This study recruited one pregnant woman, who ingested Probio-M9 daily from 35 weeks of gestation to delivery. Feces of the mother-infant pair were regularly collected from one month before delivery to 6 months of infant’s age for metagenomic sequencing. Probio-M9 genomes were mappable to all infant fecal samples, suggesting the ingested probiotics could be vertically transmitted from mother to infant. Infant- or mother-specific differential metabolic pathways were found between the maternal and infant’s gut microbiome, implicating apparent differences in the intestinal metagenomic potential/function between the mother and the infant. In conclusion, maternal ingestion of Probio-M9 during the final weeks of gestation could deliver to the infant gut. The findings provided novel insights into shaping infant’s gut microbiota.}
}