@article{Yu2024, 
author = {Zhihui Yu and Lingyu Fan and Fei Tai and Lixin Zhang and Xiaoyu Zhang and Yisheng Chen},
title = {Yolk free egg substitute improves the serum phospholipid profile of mice with metabolic syndrome based on lipidomic analysis},
year = {2024},
journal = {Food Science and Human Wellness},
volume = {13},
number = {1},
pages = {482-493},
keywords = {Metabolic syndrome, Whole egg, Yolk free egg substitute, Serum, Lipidomics},
url = {https://www.sciopen.com/article/10.26599/FSHW.2022.9250042},
doi = {10.26599/FSHW.2022.9250042},
abstract = {In this study, the impacts of egg consumption on mice model of metabolic syndrome (MetS) were comparatively investigated. Mice were divided into five groups (n=8): normal diet group (ND), high-fat diet group (HFD), HFD with whole egg group (WE), HFD with free-yolk egg substitute group (YFES), and HFD with lovastatin group (Lov). Main biochemical indexes and a non-targeted lipidomic analysis were employed to insight the lipid profile changes in serum. It was revealed that WE could significantly improve serum biochemical indexes by reducing body weight, low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC), while increasing high-density lipoprotein cholesterol. YFES exhibited remarkably better performance in increasing phosphatidylglycerol and phosphatidic acids, while decreasing phosphatidylinositol than WE. A total of 50 differential lipids biomarkers tightly related to glycerophospholipids metabolism were screened out. Carnitine C18:2 and C12:1, SM (d18:0/12:0), and SM (d18:1/14:1) were significantly upregulated in YFES compared to WE. YFES reduced expression of SREBP-1c and Cpt1a, while did not affect the expression of PPAR-α. Sphingomyelin biomarkers were positively related to the TC (|r| > 0.6), while PPAR-α was negatively correlated with triglyceride and LDL-C levels. To sum up, YFES attenuated HFD-induced MetS by improving the serum phospholipids, which account for its modulation of glycerophospholipid metabolism.}
}