@article{Li2024, 
author = {Linzi Li and Xueying Lei and Lin Chen and Ya Ma and Jun Luo and Xuebo Liu and Xinglian Xu and Guanghong Zhou and Xianchao Feng},
title = {Protective mechanism of quercetin compounds against acrylamide-induced hepatotoxicity},
year = {2024},
journal = {Food Science and Human Wellness},
volume = {13},
number = {1},
pages = {225-240},
keywords = {Quercetin compounds, Acrylamide, Protection mechanism, Oxidative stress, Antioxidant activity},
url = {https://www.sciopen.com/article/10.26599/FSHW.2022.9250019},
doi = {10.26599/FSHW.2022.9250019},
abstract = {Quercetin compounds have antioxidant, anti-inflammatory and anticancer pharmacological functions. Longterm exposure to acrylamide (AA) can cause liver injury and endanger human health. However, whether quercetin compounds can attenuate AA-induced liver injury and the specific mechanism are not clear. Here, we studied the mechanism and structure-activity relationship of quercetin compounds in reducing AA-induced hepatotoxicity in vivo and in vitro. In vivo studies found that quercetin-like compounds protect against AA-induced liver injury by reducing oxidative stress levels, activating the Akt/mTOR signaling pathway to attenuate autophagy, and improving mitochondrial apoptosis and endoplasmic reticulum stress-mediated apoptosis. In vitro studies found that quercetin compounds protected HepG2 cells from AA by attenuating the activation of AA-induced autophagy, lowering reactive oxygen species (ROS) levels by exerting antioxidant effects and thus attenuating oxidative stress, increasing mitochondrial membrane potential (MMP), and improving apoptosis-related proteins, thus attenuating AA-induced apoptosis. Furthermore, the conformational differences between quercetin compounds correlated with their protective capacity against AA-induced hepatotoxicity, with quercetin showing the best protective capacity due to its strongest antioxidant activity. In conclusion, quercetin compounds can protect against AA-induced liver injury through multiple pathways of oxidative stress, autophagy and apoptosis, and their protective capacity correlates with antioxidant activity.}
}