@article{Li2024, 
author = {Xueqi Li and Wenjun Ma and Ting Yang and Chong Wang and Wei Zhang and Hui Li and Ting Zhao and Xiaofei Guo},
title = {Higher intakes of lysine, threonine and valine are inversely associated with non-alcoholic fatty liver disease risk: a community-based case-control study in the Chinese elderly},
year = {2024},
journal = {Food Science and Human Wellness},
volume = {13},
number = {1},
pages = {191-197},
keywords = {Amino acid, Non-alcoholic fatty liver disease, Senior citizen, Dose-response analysis},
url = {https://www.sciopen.com/article/10.26599/FSHW.2022.9250016},
doi = {10.26599/FSHW.2022.9250016},
abstract = {The associations of individual amino acid with non-alcoholic fatty liver disease (NAFLD) risk remained unclear. The present study aimed to investigate the associations between the two in the Chinese elderly. Methods: A community-based health check-up program was conducted in Qingdao, China. NAFLD was diagnosed by ultrasonography accompanied by epidemiological investigation. The dietary intakes of amino acids were investigated with 3-day, 24-h dietary records and calculated by Nutrition Calculator software. Restricted cubic spline model was used to evaluate a nonlinear relationship between amino acid intake and NAFLD risk. Results: 400 NAFLD subjects were identified, and 400 participants were randomly selected as controls and matched by gender and age (± 3 years) Dose-response analysis showed that 1000 mg increment of aromatic amino acids (AAAs) was associated with reduced 16% risk of NAFLD. Dietary increments of 750 mg/d threonine, 950 mg/d valine, or 1700 mg/d lysine were associated with a 20% reduction in the NAFLD risk (all P for linearity < 0.05). Conclusion: The present study demonstrated that the dietary increases in milk, eggs and deep-sea fish, which are rich in the amino acids, might contribute to protecting against NAFLD in the elderly.}
}