@article{Widysanto2022, 
author = {Allen Widysanto and Ignatius Bima Prasetya and Tandry Meriyanti and Veli Sungono and Diane Lukito Setiawan and Edy Gunawan and Bayu Adiputra and Jane Olivia Lorens and Theresia Santi and Cindy Meidy Leony Pradhana and Irawan Yusuf and Catherine Gunawan},
title = {The risk factors of SARS-CoV-2 antibody level differences in healthcare workers post vaccination in Siloam hospitals: A nationwide multicenter study},
year = {2022},
journal = {Infectious Medicine},
volume = {1},
number = {4},
pages = {229-235},
keywords = {Antibodies titer, COVID-19, Immune response, S-RBD IgG, Vaccine},
url = {https://www.sciopen.com/article/10.1016/j.imj.2022.10.001},
doi = {10.1016/j.imj.2022.10.001},
abstract = {BackgroundSeveral vaccines have been approved against COVID-19, and 5 have been used in Indonesia. Due to the decrease in antibody levels 3 to 6 months after the second dose of CoronaVac, healthcare workers received the third booster of mRNA vaccine (mRNA-1273) to increase the antibody level. This study aimed to evaluate the risk factors of anti-S-RBD IgG levels differences in healthcare workers.MethodsThis study is a retrospective cohort study of 576 healthcare workers without previous SARS-CoV-2 infection who received 2 doses of CoronaVac and the third dose of mRNA-1273 6 months after the second dose. Blood samples were obtained 2nd, 6th, 12th, and 24th weeks after the second dose of CoronaVac vaccine administration, with mRNA-1273 booster on week 20. Quantitative measurements of IgG antibodies were performed with Elecsys Anti-SARS-CoV-2 S immunoassay. We identify the baseline factors predicting post-vaccination antibody titers using univariate and multivariate linear regression analysis.ResultsThis study comprised 576 participants aged 32 years old, 72.05% female, and 45.84% from high-risk occupation subgroups. The median antibodies titer level on the 2nd, 6th, 12th, and 24th weeks after the second vaccine dose administration were 40.99 u/mL, 42.01 u/mL, 54.78 u/mL, and 23,225 u/mL. Antibody levels trended highest in female and younger age group (20-29 years old).ConclusionsThe third dose of vaccine increased the quantitative SARS-CoV-2 spike IgG antibody titers and eliminated differences in antibodies titer by gender.}
}