@article{WEI2023, 
author = {Qiangbing WEI and Tian FU and Lele LEI and Huan LIU and Yixin ZHANG and Shuanhong MA and Feng ZHOU},
title = {Dopamine-triggered one-step functionalization of hollow silica nanospheres for simultaneous lubrication and drug release},
year = {2023},
journal = {Friction},
volume = {11},
number = {3},
pages = {410-424},
keywords = {osteoarthritis treatment, functionalized nanoparticles, injectable biolubricant, friction reduction, drug release},
url = {https://www.sciopen.com/article/10.1007/s40544-022-0605-x},
doi = {10.1007/s40544-022-0605-x},
abstract = {Osteoarthritis (OA) has been regarded as a lubrication deficiency related joint disease. Combination of both joint lubrication and drug intervention may provide a promising nonsurgical strategy for treatment of OA. Developing novel and simple approaches to fabricate superlubricating nanoparticles with drug release property is highly required. Herein, dopamine triggered one-step polymerization method was employed to fabricate polydopamine/poly(3-sulfopropyl methacrylate potassium salt) (PDA–PSPMA) conjugate coating on hollow silica (h-SiO2) nanosphere surfaces to engineer functional nanoparticles (h-SiO2/PDA–PSPMA). The as-prepared h-SiO2/PDA–PSPMA exhibits excellent aqueous lubrication performance on biomaterial substrates as well as natural bovine articular cartilage based on hydration effect of negatively charged PDA–PSPMA coating and "rolling" effect of h-SiO2 nanospheres. In vitro drug loading-release experiments demonstrate that PDA–PSPMA coating functionalized h-SiO2 nanospheres show high drug-loading and sustained-release capability of an anti-inflammatory drug, diclofenac sodium (DS). Such h-SiO2/PDA–PSPMA nanospheres can be potentially used as a synergistic therapy agent for OA treatment combining by simultaneous joint lubrication and drug release.}
}