@article{Gui2023, 
author = {Liang Gui and Juju Huang and Yi Xing and Yongjun Li and Junjie Zou and Yingwei Zhu and Xiao Liang and Xiwei Zhang and Qiang Xu and Xin Du},
title = {Near-infrared light-driven multifunctional metal ion (Cu2+)-loaded polydopamine nanomotors for therapeutic angiogenesis in critical limb ischemia},
year = {2023},
journal = {Nano Research},
volume = {16},
number = {4},
pages = {5108-5120},
keywords = {copper, polydopamine, nanomotors, near-infrared (NIR) light, therapeutic angiogenesis},
url = {https://www.sciopen.com/article/10.1007/s12274-022-5356-2},
doi = {10.1007/s12274-022-5356-2},
abstract = {Most of the current nanomedicine-based treatments for critical limb ischemia (CLI) only aim at promoting angiogenesis, ignoring the negative influence on the therapeutic effects caused by the complex pathological micro-environment of ischemic tissue. Herein, near-infrared (NIR) light-driven metal ion (Cu2+)-loaded polydopamine (PDA) nanomotors (JMPN@Cu2+) is designed and prepared. Due to the good antioxidant and anti-inflammatory activities of PDA, JMPN@Cu2+ exhibits excellent biocompatibility and significantly improves the ischemic micro-environment. Additionally, based on superior photothermal conversion effect and jellyfish-like structure, the nanomotors are quickly propelled under NIR laser with low energy intensity to acquire the ability of movement and facilitate intracellular uptake of JMPN@Cu2+ by endothelial cells, resulting in the enhanced pro-angiogenic effect of Cu2+. Moreover, in vivo experimental findings show that JMPN@Cu2+ combined with NIR irradiation can successfully accelerate blood flow recovery and improve muscle repair. Taking these results together, this kind of nanomotor can promote angiogenesis along with ischemic micro-environment amelioration, holding great potential applications for the treatment of limb ischemia.}
}