@article{Lin2023, 
author = {Lihong Lin and Heng Li and Hongfei Gu and Zhiyi Sun and Juan Huang and Zhenni Qian and Hang Li and Juzhe Liu and Hongyan Xi and Pengfei Wu and Qingqing Liu and Shuhu Liu and Lirong Zheng and Zhuo Chen and Zhengbo Chen and Juanjuan Qi},
title = {Asymmetrically coordinated single-atom iron nanozymes with Fe-N1C2 structure: A peroxidase mimetic for melatonin detection},
year = {2023},
journal = {Nano Research},
volume = {16},
number = {4},
pages = {4751-4757},
keywords = {nanozyme, iron single atom, asymmetric coordination, Ti3C2Tx MXene, melatonin detection},
url = {https://www.sciopen.com/article/10.1007/s12274-022-5211-8},
doi = {10.1007/s12274-022-5211-8},
abstract = {Owing to the unique coordination environment and high atom utilization efficiency, single atom catalysts have been considered as an ideal artificial enzyme to mimic natural enzymes. Herein, single-atom Fe nanozyme anchored on N-doped Ti3C2Tx (Fe SA/N-Ti3C2Tx) with asymmetrically coordinated Fe-N1C2 configuration is synthesized by vacancy capture and heteroatom doping strategy, which exhibits excellent peroxidase-like activity. Based on the results of peroxidase catalytic kinetics and X-ray adsorption fine spectroscopy, the Fe-N1C2 active sites in Fe SA/N-Ti3C2Tx are responsible for the excellent performance. Furthermore, the developed Fe SA/N-Ti3C2Tx can be employed to quantitative detection of melatonin (MT), which shows a wide linear detection range (0.01–100 μM) and an excellent detection limit (7.3 nM) in buffer, 0.01–100 μM and 7.8 nM in serum samples. Our work proves that MXene-based single atoms can be promising nanozyme in the field of bioassays.}
}