@article{Zhu2023, 
author = {Liye Zhu and Hong Zhong and Dan Du and Tao Li and Hoai Nguyen and Scott P. Beckman and Wentao Xu and Jin-Cheng Li and Nan Cheng and Yuehe Lin},
title = {A peroxidase-like single-atom Fe-N5 active site for effective killing human lung adenocarcinoma cells},
year = {2023},
journal = {Nano Research},
volume = {16},
number = {4},
pages = {5216-5225},
keywords = {single-atom catalyst, three-dimensional (3D), cancer cell model, peroxidase-like catalytic activity, cancer therapy},
url = {https://www.sciopen.com/article/10.1007/s12274-022-5127-3},
doi = {10.1007/s12274-022-5127-3},
abstract = {Single-atom catalyst (SAC) is one of the newest catalysts, and attracts people’s wide attention in cancer therapy based on their characteristics of maximum specific catalytic activity and high stability. We designed and synthesized a Fe-N decorated graphene nanosheet (Fe-N5/GN SAC) with the coordination number of five. Through enzymology and theoretical calculations, the Fe-N5/GN SAC has outstanding intrinsic peroxidase-like catalytic activity due to single-atom Fe site with five-N-coordination structure. We explored its potential on lung cancer therapy, and found that it could kill human lung adenocarcinoma cells (A549) by decomposing hydrogen peroxide (H2O2) into toxic reactive oxygen species (ROS) under acidic microenvironment in three-dimensional (3D) lung cancer cell model. Our study demonstrates a promising application of SAC with highly efficient single-atom catalytic sites for cancer treatment.}
}