@article{Zhou2023, 
author = {Liang Zhou and Xiaohui Sun and Jingjing Duan},
title = {NMDARs regulate the excitatory-inhibitory balance within neural circuits},
year = {2023},
journal = {Brain Science Advances},
volume = {9},
number = {1},
pages = {3-14},
keywords = {NMDAR, AMPAR, GABAAR, excitatory-inhibitory balance, neurological disorders},
url = {https://www.sciopen.com/article/10.26599/BSA.2022.9050020},
doi = {10.26599/BSA.2022.9050020},
abstract = {Excitatory-inhibitory (E/I) balance is essential for normal neural development, behavior and cognition. E/I imbalance leads to a variety of neurological disorders, such as autism and schizophrenia. NMDA receptors (NMDARs) regulate AMPAR-mediated excitatory and GABAAR-mediated inhibitory synaptic transmission, suggesting that NMDARs play an important role in the establishment and maintenance of the E/I balance. In this review, we briefly introduced NMDARs, AMPARs and GABAARs, summarized the current studies on E/I balance mediated by NMDARs, and discussed the current advances in NMDAR-mediated AMPAR and GABAAR development. Specifically, we analyzed the role of NMDAR subunits in the establishment and maintenance of E/I balance, which may provide new therapeutic strategies for the recovery of E/I imbalance in neurological disorders.}
}