TY  - JOUR
AU  - Zayet, Souheil
AU  - Zahra, Hajer
AU  - Belfeki, Nabil
AU  - Klopfenstein, Timothée
AU  - Hagenkötter, Beate
PY  - 2022
TI  - Atypical miller-fisher syndrome after COVID-19 and sleeve gastrectomy: Contribution of neurochemical markers to early diagnosis
JO  - Infectious Medicine
SN  - 2097-0684
SP  - 140
EP  - 142
VL  - 1
IS  - 2
AB  - BackgroundThe coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), began in late 2019. More recently, there have been sporadic case reports on development of Miller-Fisher Syndrome, a rare variant of Guillain-Barré Syndrome in COVID-19 patients.Case reportWe reported herein the case of a French young women presenting with ophtalmoplegia, cerebellar ataxia, and universal areflexia following a bariatric surgery (sleeve gastrectomy). A concomitant COVID-19 diagnosis was retained based on microbiological testing. The patient was successfully treated after high-dose intravenous thiamine, but areflexia persisted. Underlying COVID-19 related Miller-Fisher Syndrome was established on physical examination and confirmed by pathologic neurophysiological findings and elevated level of phosphorylated neurofilament heavy chain protein in cerebrospinal fluid analysis.ConclusionsGuillain-Barré Syndrome and its variants after SARS-CoV-2 infection are extremely rare. The measurement of phosphorylated neurofilament heavy chain protein should be considered as an easy tool to detect an early affection of the peripheral nervous system.
UR  - https://doi.org/10.1016/j.imj.2022.02.001
DO  - 10.1016/j.imj.2022.02.001