@article{MIAO2022, 
author = {Chao-Ying MIAO and Xiao-Fei YE and Wei ZHANG and Chang-Sheng SHENG and Qi-Fang HUANG and Ji-Guang WANG},
title = {Serum triglycerides concentration in relation to total and cardiovascular mortality in an elderly Chinese population},
year = {2022},
journal = {Journal of Geriatric Cardiology},
volume = {19},
number = {8},
pages = {603-609},
url = {https://www.sciopen.com/article/10.11909/j.issn.1671-5411.2022.08.007},
doi = {10.11909/j.issn.1671-5411.2022.08.007},
abstract = {OBJECTIVETo investigate serum triglycerides in relation to all-cause, cardiovascular, and non-cardiovascular mortality in an elderly Chinese population.METHODSThe study participants (n = 3565) were elderly (≥ 60 years) community dwellers living in a suburban town of Shanghai. Hypertriglyceridemia was defined as a serum triglycerides concentration ≥ 2.30 mmol/L (definite) and ≥ 1.70 mmol/L (borderline), respectively.RESULTSThe prevalence of definite and borderline hypertriglyceridemia at baseline was 7.5% and 29.5%, respectively. It was higher in women (n = 1982, 9.0% and 33.8%, respectively) than men (n = 1583, 6.2% and 27.9%, respectively), in obese and overweight participants (n = 1566, 10.5% and 36.4%, respectively) than normal weight participants (n = 1999, 5.6% and 27.1%, respectively), and in diabetic participants (n = 177, 11.9% and 39.0%, respectively) than non-diabetic participants (n = 3388, 7.5% and 30.8%, respectively). During a median of 7.9 years follow-up, all-cause, cardiovascular and non-cardiovascular deaths occurred in 529, 216 and 313 participants, respectively. In analyses according to the quintile distributions of serum triglycerides concentration, the sex- and age-standardized mortality rate was lowest in the middle quintile for all-cause, cardiovascular and non-cardiovascular mortality (18.6, 7.8 and 11.9 per 1000 person-years, respectively, versus 21.5, 10.5 and 12.7 per 1000 person-years, respectively, in the two lower quintiles and 21.7, 9.5 and 14.0 per 1000 person-years, respectively, in the two higher quintiles). The fully adjusted hazard ratios (95% CI) for the middle quintile versus the combined two lower with two higher quintiles were 0.85 (95% CI: 0.67–1.07, P = 0.17), 0.81 (95% CI: 0.54–1.19, P = 0.28) and 0.87 (95% CI: 0.64–1.17, P = 0.35) for all-cause, cardiovascular and non-cardiovascular mortality, respectively.CONCLUSIONSOur study showed high prevalence of hypertriglyceridemia, especially when defined as borderline and in obese and overweight participants, and mildly but non-significantly elevated risks of cardiovascular mortality relative to the middle level of serum triglycerides.}
}