@article{Cheng2017, 
author = {Zhijian Cheng and Xijing He},
title = {Anti-inflammatory effect of stem cells against spinal cord injury via regulating macrophage polarization},
year = {2017},
journal = {Journal of Neurorestoratology},
volume = {5},
number = {1},
pages = {31-38},
keywords = {stem cells, macrophages, spinal cord injury, polarization},
url = {https://www.sciopen.com/article/10.2147/JN.S115696},
doi = {10.2147/JN.S115696},
abstract = {Spinal cord injury (SCI) is a traumatic event that involves not just an acute physical injury but also inflammation-driven secondary injury. Macrophages play a very important role in secondary injury. The effects of macrophages on tissue damage and repair after SCI are related to macrophage polarization. Stem cell transplantation has been studied as a promising treatment for SCI. Recently, increasing evidence shows that stem cells, including mesenchymal stem, neural stem/progenitor, and embryonic stem cells, have an anti-inflammatory capacity and promote functional recovery after SCI by inducing macrophages M1/M2 phenotype transformation. In this review, we will discuss the role of stem cells on macrophage polarization and its role in stem cell-based therapies for SCI.}
}