@article{Liu2022, 
author = {Taiyu Liu and Lu Li and Cheng Cheng and Bingfang He and Tianyue Jiang},
title = {Emerging prospects of protein/peptide-based nanoassemblies for drug delivery and vaccine development},
year = {2022},
journal = {Nano Research},
volume = {15},
number = {8},
pages = {7267-7285},
keywords = {self-assembly, drug delivery, vaccine, controlled release, targeting, protein/peptide},
url = {https://www.sciopen.com/article/10.1007/s12274-022-4385-4},
doi = {10.1007/s12274-022-4385-4},
abstract = {Proteins have been widely used in the biomedical field because of their well-defined architecture, accurate molecular weight, excellent biocompatibility and biodegradability, and easy-to-functionalization. Inspired by the wisdom of nature, increasing proteins/peptides that possess self-assembling capabilities have been explored and designed to generate nanoassemblies with unique structure and function, including spatially organized conformation, passive and active targeting, stimuli-responsiveness, and high stability. These characteristics make protein/peptide-based nanoassembly an ideal platform for drug delivery and vaccine development. In this review, we focus on recent advances in subsistent protein/peptide-based nanoassemblies, including protein nanocages, virus-like particles, self-assemblable natural proteins, and self-assemblable artificial peptides. The origin and characteristics of various protein/peptide-based assemblies and their applications in drug delivery and vaccine development are summarized. In the end, the prospects and challenges are discussed for the further development of protein/peptide-based nanoassemblies.}
}