@article{Li2022, 
author = {Xiao-Rui Li and Baoli Yin and Lei Gao and Xinhao Li and Hongwen Huang and Guosheng Song and Yi-Ge Zhou},
title = {One-step reduction-encapsulated synthesis of Ag@polydopamine multicore-shell nanosystem for enhanced photoacoustic imaging and photothermal-chemodynamic cancer therapy},
year = {2022},
journal = {Nano Research},
volume = {15},
number = {9},
pages = {8291-8303},
keywords = {one-step synthesis, photoacoustic imaging, multicore-shell nanosystem, enhanced photothermal therapy, dual tumor microenvironment-coactivated chemodynamic therapy},
url = {https://www.sciopen.com/article/10.1007/s12274-022-4474-4},
doi = {10.1007/s12274-022-4474-4},
abstract = {Though imaging-guided multimodal therapy has been demonstrated as an effective strategy to improve cancer diagnosis and therapy, challenge remains as to simplify the sophisticated synthesis procedure for the corresponding nanoagents. Herein, an in-situ one-step reduction-encapsulated method has been reported, for the first time, to synthesize multicore-shell polydopamine-coated Ag nanoparticles (AgNPs@PDA) as a cancer theranostic agent, integrating amplified photoacoustic imaging, enhanced photothermal therapy, and photothermal promoted dual tumor microenvironment-coactivated chemodynamic therapy. The photoacoustic signal and the photothermal conversion efficiency of AgNPs@PDA nanosystem present a 6.6- and 4.2-fold enhancement compared to those of M-AgNPs-PDA (simply mixing PDA and AgNPs) derived from the increased interface heat transfer coefficient and the stronger near-infrared absorption. Importantly, AgNPs@PDA coactivated by dual tumor microenvironment (TME) enables controllable long-term release of hydroxyl radicals (·OH) and toxic Ag+, which can be further promoted by near-infrared light irradiation. Moreover, the high efficiency of AgNPs@PDA nanosystem with prominent photoacoustic imaging-guided synergistic photothermal-chemodynamic cancer treatment is also found in in vitro and in vivo studies. As a special mention, the formation mechanism of the one-step synthesized multicore-shell nanomaterials is systematically investigated. This work provides a much simplified one-step synthesis method for the construction of a versatile nanoplatform for cancer theranostics with high efficacy.}
}