@article{Xu2022, 
author = {Lina Xu and Jingshan Chai and Ying Wang and Xinzhi Zhao and Dong-Sheng Guo and Linqi Shi and Zhanzhan Zhang and Yang Liu},
title = {Calixarene-integrated nano-drug delivery system for tumor-targeted delivery and tracking of anti-cancer drugs in vivo},
year = {2022},
journal = {Nano Research},
volume = {15},
number = {8},
pages = {7295-7303},
keywords = {drug delivery system, calixarene, host–guest interaction, hypoxia-responsiveness, drug tracking},
url = {https://www.sciopen.com/article/10.1007/s12274-022-4332-4},
doi = {10.1007/s12274-022-4332-4},
abstract = {Nano-drug delivery systems (nanoDDS) have been extensively investigated clinically to improve the therapeutic effect of anti-cancer drugs. However, the complicated synthesis during the preparation as well as the potential drug leakage during transportation has greatly limited their general application. In this work, a calixarene-integrated nanoDDS (CanD) that achieves tumor-targeted delivery and tracking of anti-cancer drugs in vivo is presented. The hypoxia-responsive calixarene (SAC4A) exhibits high binding affinity to a series of anti-cancer drugs and rhodamine B (RhB) under normoxic condition while decreasing the binding affinity under hypoxic condition, which leads to the drug release and fluorescence recovery simultaneously. Furthermore, the hypoxia-responsiveness of SAC4A conveys CanD with tumor-targeting ability, resulting in the enrichment of the drug in tumors and enhancement in tumor suppression in mice. Moreover, CanD could become a general platform allowing the delivery of a wide scope of anti-cancer drugs that have strong host-guest interaction with SAC4A.}
}