@article{Wang2022, 
author = {Jinghan Wang and Shanqing Gao and Xiao Wang and Haozhen Zhang and Xitong Ren and Juewen Liu and Feng Bai},
title = {Self-assembled manganese phthalocyanine nanoparticles with enhanced peroxidase-like activity for anti-tumor therapy},
year = {2022},
journal = {Nano Research},
volume = {15},
number = {3},
pages = {2347-2354},
keywords = {self-assembly, nanozymes, manganese phthalocyanine, peroxidase, catalytic therapy},
url = {https://www.sciopen.com/article/10.1007/s12274-021-3854-5},
doi = {10.1007/s12274-021-3854-5},
abstract = {The use of functional nanoparticles as peroxidase-like (POD-like) catalyst has recently become a focus of research in cancer therapy. Phthalocyanine is a macrocyclic conjugated metal ligand, which is expected to achieve a high POD-like catalytic activity, generating free radicals and inhibiting the proliferation of cancer cells. In this paper, we synthesized phthalocyanine nanocrystals with different structures through noncovalent self-assembly confined within micro-emulsion droplets, and manganese phthalocyanine (MnPc) possessing a metal–N–C active center was used as the building block. These nano-assemblies exhibit shape-dependent POD-like catalytic activities, because the emulsifier and MnPc co-mixed assembly reduced the close packing between MnPc molecules and exposed more active sites. The assembly had a water-dispersed nanostructure, which is conducive to accumulation at tumor sites through the enhanced permeability and retention effect (EPR). Because of a highly efficient microenvironmental response, the assembly showed higher catalytic activity only emerged under the acidic tumor-like microenvironment, but caused less damage to normal tissues in biomedical applications. In vivo and in vitro catalytic therapy tests showed excellent anti-tumor effects. This work explored a new way for the application of metal–organic macromolecules such as MnPc as nanozymes for catalytic tumor therapy.}
}