@article{Ma2022, 
author = {Yuanyuan Ma and Zhongju Ye and Chen Zhang and Yanjun Zhao and Hai-bin Luo and Lehui Xiao},
title = {Curved carbon photo-oxygenation catalysts for the suppression and nanoscopic imaging of β-amyloid peptides fibrillation},
year = {2022},
journal = {Nano Research},
volume = {15},
number = {4},
pages = {3387-3397},
keywords = {fluorescence imaging, β-amyloid, reactive oxygen species, nanoscopic imaging, fibrillation},
url = {https://www.sciopen.com/article/10.1007/s12274-021-3927-5},
doi = {10.1007/s12274-021-3927-5},
abstract = {The progression of Alzheimer’s disease (AD) is characterized with the deposition and aggregation of β-amyloid (Aβ). Visualizing Aβ aggregates at high spatial resolution is beneficial for AD diagnosis and treatment. Herein, we designed a new molecule by conjugating corannulene (Cor) with rhodamine B isothiocyanate (Rhb), namely Cor-Rhb, for the nanoscopic imaging and modulating Aβ peptide fibrillation. The low duty cycle, high photon output and sufficient switching cycles enable Cor-Rhb suitable for localization-based nanoscopic fluorescence imaging. We find that Cor-Rhb can inhibit Aβ peptides fibrillization and interact directly with mature fibrils, triggering their disaggregation under light illumination. Noticeably reduced Aβ-mediated cytotoxicity after the addition of Cor-Rhb is also confirmed. These explorations suggest that Cor-Rhb displays great potential as a multifunctional therapeutic agent against amyloid-related diseases, and may largely facilitate a variety of super-resolution based biological applications.}
}