@article{Zhou2022, 
author = {Zhiqiang Zhou and Fei Gong and Peng Zhang and Xiaotong Wang and Rui Zhang and Wei Xia and Xiang Gao and Xiaozhong Zhou and Liang Cheng},
title = {Natural product curcumin-based coordination nanoparticles for treating osteoarthritis via targeting Nrf2 and blocking NLRP3 inflammasome},
year = {2022},
journal = {Nano Research},
volume = {15},
number = {4},
pages = {3338-3345},
keywords = {iron-curcumin-based coordination nanoparticles (Fe-Cur NPs), reactive oxygen/nitrogen species (ROS/RNS) scavenging ability, osteoarthritis, antioxidation and anti-inflammation performance, signaling pathway},
url = {https://www.sciopen.com/article/10.1007/s12274-021-3864-3},
doi = {10.1007/s12274-021-3864-3},
abstract = {Oxidative stress leads to chondrocyte apoptosis and extracellular matrix (ECM) degradation, thus contributing to the pathogenesis of osteoarthritis (OA). Herein, curcumin with remarkable antioxidant and anti-inflammatory activities has been employed as an organic ligand to coordinate ferric ions for enhancing the water-solubility and biocompatibility of natural product curcumin. The obtained iron-curcumin-based coordination nanoparticles (Fe-Cur NPs) exhibit great water-solubility and efficient reactive oxygen/nitrogen species (ROS/RNS) scavenging ability. In vitro chondrocyte evaluation experiments indicated that the intracellular ROS/RNS induced by interleukin 1β (IL-1β) could be efficiently scavenged by these Fe-Cur NPs and oxidative-stress-induced cell death could be preserved as well. In addition, post intra-articular (i.a.) injection into OA rat joints, Fe-Cur NPs could greatly inhibit OA progression via activating the nuclear factor-erythroid 2 related factor-2 (Nrf2) and inhibiting nod-like receptor protein-3 (NLRP3) inflammasome activation in primary rat chondrocytes, as well as decrease the production of matrix degrading proteases and other inflammatory mediators. The efficient antioxidation and anti-inflammation performance of Fe-Cur NPs endow them as a promising nanoplatform for treatment of various inflammatory diseases, and more detailed researches will be conducted in the future.}
}